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It’s also the hormone most closely linked to male sexuality, and it’s responsible for the development of sexual organs and sperm. This means your doctor may need to get approval from your insurance company before your insurance company will pay for the prescription. From this information, it is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors [see ADVERSE REACTIONS].

Histological examination of the brains of dogs that were killed acutely after irradiation did not show evidence of inflammation, edema, or hemorrhage. Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. It is therefore recommended not to exceed a maximum single dose of 25 mg of VIAGRA in a 48 hour period [see DOSAGE AND ADMINISTRATION, WARNINGS AND PRECAUTIONS, CLINICAL PHARMACOLOGY]. This does depend on the individual, but this is the case for most men.

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24, are believed to be the first confirmation in humans that sildenafil has a direct effect on the heart.  Previous research by Kass and his team showed that sildenafil had such effects in mice, blocking the short-term effects of hormonal stress in the heart.  Related studies by the group also showed that sildenafil prevents and reverses the long-term effects in the heart from chronic high blood pressure.  Moreover, Kass adds, the latest Hopkins results confirm that sildenafil helps control heart function only when the heart is under duress, but has little impact under normal conditions. It is possible to enjoy alcohol when using Viagra, but remember to drink moderate amounts only.

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However, taking it may cause a range of adverse effects. Symptoms may include swelling, pain, and problems with urination. A: Viagra (sildenafil) (//www.everydayhealth.com/drugs/viagra) is a phosphodiesterase type 5 inhibitor (PDE5).

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There are no controlled clinical data on the safety or efficacy of VIAGRA in the following groups; if prescribed, this should be done with caution. Increased side effects can include blood pressure that’s too low. Pharmaceutical companies must pay for years of clinical trials before a drug can be deemed safe by the FDA to be on the market. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. For the 17 subjects who received VIAGRA 25 mg and matching placebo, the placebo-subtracted mean maximum decreases from baseline (95% CI) in systolic blood pressure were as follows: The mean profiles of the change from baseline in standing systolic blood pressure in subjects treated with doxazosin in combination with 25 mg VIAGRA or matching placebo are shown in Figure 2. Most, but not all of these men, had heart problems before taking this medication. Viagra should be used with caution in patients with heart disease, including arrhythmias (abnormal heart rhythms); a recent history (in the past 6 months) of a heart attack, stroke, or heart rhythm disorder; congestive heart failure; high or low blood pressure; and coronary artery disease. The cause is usually related to a decrease in the blood supply to the penis as well as to injury to the nerves that are responsible for the erection mechanism. This decrease was seen at one to two hours after taking the medication. This can help prevent dangerously low blood pressure. Zusman RM, Morales A, Glasser DB, Osterloh IH "Overall cardiovascular profile of sildenafil citrate." Am J Cardiol 83 (1999): c35-44 22.