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In Vivo Studies No significant interactions were shown with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolized by CYP2C9. Viagra or generic sildenafil for ED should not be used in women. Egan R, Pomeranz H "Sildenafil (Viagra) associated anterior ischemic optic neuropathy." Arch Ophthalmol 118 (2000): 291-2 42.

Viagra’s effects typically last for between four and six hours, and it should not be taken unless you intend to have sex. On a global improvement question, 57% of VIAGRA patients reported improved erections versus 10% on placebo. The AUC of the active metabolite, N-desmethyl sildenafil, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers.

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If you're currently taking Viagra in a 50mg dosage, and find the effects to be ideal, you can transition to Viagra Connect. Your healthcare provider may change your dose if needed. Oh, I haven't ever taken it, but I think the drug that tonyad mentioned is Cisapride, which got pulled for causing (I think) strokes? The safety of VIAGRA is unknown in patients with bleeding disorders and patients with active peptic ulceration.

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Doses may range from 5 mg to 20 mg depending on efficacy and patient tolerability. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). They can also include erections that last longer than normal.

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Among the roughly equal control group, just three babies had lung problems and none died. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic effects. Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex. Figure 6: Effect of VIAGRA and Placebo on Maintenance of Erection by Baseline Score The frequency of patients reporting improvement of erections in response to a global question in four of the randomized, double-blind, parallel, placebo-controlled fixed dose studies (1797 patients) of 12 to 24 weeks duration is shown in Figure 7.