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Interaction With Other Drugs Viagra side effects may be increased by certain other medications – it is not recommended to mix some medicines. This is because the fat in your digestive system causes the medication to enter your blood more slowly. Sildenafil, the active ingredient in Viagra, is also marketed as Revatio, which is indicated for the treatment of pulmonary arterial hypertension to improve exercise ability and delay clinical worsening in men and women. It’s prescribed by approved providers in agreement between the manufacturer and the FDA. In a study of healthy male volunteers, co-administration of sildenafil at steady state (80 mg t.i.d.) with endothelin receptor antagonist bosentan (a moderate inducer of CYP3A4, CYP2C9 and possibly of CYP2C19) at steady state (125 mg b.i.d.) resulted in a 63% decrease of sildenafil AUC and a 55% decrease in sildenafil Cmax .

The word Viagra is the brand name for sildenafil citrate and is used to treat erectile dysfunction and pulmonary arterial hypertension. If you usually take another ED brand, or a different dosage, you may wish to discuss switching to Viagra Connect with your doctor first. Viagra relaxes muscles and increases the blood flow to particular areas of the body. In addition, in a study performed in healthy male volunteers, co-administration of the HIV protease inhibitor saquinavir, also a CYP3A4 inhibitor, at steady state (1200 mg tid) with Viagra (100 mg single dose) resulted in a 140% increase in sildenafil Cmax and a 210% increase in sildenafil AUC. It is important to avoid nitroglycerin while taking these medications, but work is being done to develop a similar medication that can be taken with nitroglycerin.

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Viagra begins to exert its therapeutic effect within one hour with the duration of effects lasting for up to four hours. After the first injection of dobutamine, the force of heart contraction increased by 150 percent in both groups.  And in the placebo group, this increase repeated itself after the second injection.  However, in the group treated with sildenafil, the increased heartbeat was slowed by 50 percent, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical stimulation. Guanylate Cyclase (GC) Stimulators Physicians should discuss with patients the contraindication of VIAGRA with use of guanylate cyclase stimulators such as riociguat [see CONTRAINDICATIONS]. For further information: //www.everydayhealth.com/erectile-dysfunction/guide/ Q: Does Viagra work for women? Given sildenafil peak plasma concentrations of approximately 1 μM after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes. Serious side effects and their symptoms can include the following: Low blood pressure.

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Before you take VIAGRA, tell your healthcare provider if you: have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve or heart failure have had heart surgery within the last 6 months have pulmonary hypertension have had a stroke have low blood pressure, or high blood pressure that is not controlled have a deformed penis shape have had an erection that lasted for more than 4 hours have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia have retinitis pigmentosa, a rare genetic (runs in families) eye disease have ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) have bleeding problems have or have had stomach ulcers have liver problems have kidney problems or are having kidney dialysis have any other medical conditions Tell your healthcare provider about all the medicines you take*, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Viagra exhibits no therapeutic responses in the absence of sexual stimulation. But, Viagra use in individuals without erectile dysfunction does not seem to have any effect.

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Viagra (sildenafil)." Pfizer US Pharmaceuticals, New York, NY. When they looked at the individual measures, they found women treated with Viagra were significantly more likely to reach orgasm than those in the placebo group. It is an expensive medication and will not be available as a generic for a few more years. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. Considerably lower activities were ascertained in kidneys, brain, lungs, and heart. Binding Characteristics Studies in vitro have shown that sildenafil is selective for PDE5. But then on march 17 of 2007 my husband had a heart attack with minimal damage to the heart muscle, but had to have 2 stints placed to open a large vessel that was blocked.