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Nitric oxide allows the smooth muscles inside the penis to relax, promoting more blood flow to the area during sexual arousal or stimulation. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum.

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Viagra Adverse Effects

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Other common side effects of Viagra include warmth or redness in your face, neck, or chest; stuffy nose; headache; upset stomach; and back pain. The second concern is that Viagra opens up arteries in the brain lining and can cause excess pressure causing a headache or even a heart attack.

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In the year 2000, Viagra (sildenafil) reportedly accounted for 92% of the global market for prescribed erectile dysfunction pills. Viagra is approved for the treatment of erectile dysfunction (ED).

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Histological examination of the brains of dogs that were killed acutely after irradiation did not show evidence of inflammation, edema, or hemorrhage. Because of these possible events, the patients should be monitored closely. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. It also alleviates time and energy on the NHS and other doctor's services. It was designed to look at possible beneficial effects of increased blood flow to the placenta in mothers whose unborn babies were severely underdeveloped. Pharmacokinetic data from patients in clinical trials showed no effect on sildenafil pharmacokinetics of CYP2C9 inhibitors (such as tolbutamide, warfarin), CYP2D6 inhibitors (such as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related diuretics, ACE inhibitors, and calcium channel blockers. The cause is usually related to a decrease in the blood supply to the penis as well as to injury to the nerves that are responsible for the erection mechanism.


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