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The incidents include abnormal heart rhythm (atrial fibrillation and ventricular arrhythmia), low blood pressure, myocardial infarction, and blood clots (thromboembolism). The rare side effects can include loss of vision/blindness, and a prolonged erection (greater than 4 hours). NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.

Sources say consuming a lot of alcohol over time can cause shrinkage in your testicles. Sildenafil, the active ingredient in Viagra, is also marketed as Revatio, which is indicated for the treatment of pulmonary arterial hypertension to improve exercise ability and delay clinical worsening in men and women. Protein binding is independent of total drug concentrations.

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It is not possible to determine whether these events were directly related to Viagra. Tran D, Howes LG "Cardiovascular safety of sildenafil." Drug Saf 26 (2003): 453-60 14. Although the interaction between other protease inhibitors and sildenafil has not been studied, their concomitant use is expected to increase sildenafil levels. This can cause your body to process drugs more slowly. Viagra lowers your blood pressure, as does alcohol.

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Do not give Viagra to anyone under 18 years old without medical advice. Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.

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A: It costs pharmacies a lot of money to purchase brand-name drugs from wholesalers. Viagra comes in dosages of 25mg, 50mg, and 100mg. Higher dosages may last longer, but also come with a bigger risk of side effects. Possible side effects associated with treatment with Viagra include flushed skin, nausea or abdominal pain, congestion in the nose, diarrhea, vision clouded with a blue tint, headache and digestive problems. Viagra should not be used in any patient who takes nitrates for chest pain. You can ask your healthcare provider or pharmacist for information about VIAGRA that is written for health professionals. There are ways to encourage Viagra Connect to work to its fullest. About 15 women who took the medication have not yet given birth.