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A: Viagra (sildenafil) should not be used in patients also using a nitrate drug for chest pain or heart problems. Metabolism and Excretion Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes.
During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. Viagra should be used with caution in patients with heart disease, including arrhythmias (abnormal heart rhythms); a recent history (in the past 6 months) of a heart attack, stroke, or heart rhythm disorder; congestive heart failure; high or low blood pressure; and coronary artery disease. For ED: Sildenafil works by increasing blood flow to the penis. Reported events include those with a plausible relation to drug use; omitted are minor events and reports too imprecise to be meaningful: Body as a Whole: face edema, photosensitivity reaction, shock, asthenia, pain, chills, accidental fall, abdominal pain, allergic reaction, chest pain, accidental injury.
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But, Viagra use in individuals without erectile dysfunction does not seem to have any effect. Both dosimetric methods showed a steep dose-distance fall-off relationship (proportional to the reciprocal of the cube of the distance from the probe tip). In volunteers with severe renal impairment (Clcr < 30 mL/min), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (~2 fold), approximately doubling of Cmax and AUC.
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For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.What is sildenafil, and how does it work (mechanism of action)? Bocchi EA, Guimaraes G, Mocelin A, Bacal F, Bellotti G, Ramires JF "Sildenafil effects on exercise, neurohormonal activation, and erectile dysfunction in congestive heart failure: a double-blind, placebo-controlled, randomized study followed by a prospective treatment for erectile dysfunction." Circulation 106 (2002): 1097-103 24. The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. It is not known if VIAGRA is safe and effective in women or children under 18 years of age. For more information on Viagra, visit www.everydayhealth.com/drugs. Through this action, the drugs work to fix a functional problem.
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Severe hypotension can occur when taking flibanserin with alcohol or certain medications. Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. After the first injection of dobutamine, the force of heart contraction increased by 150 percent in both groups. And in the placebo group, this increase repeated itself after the second injection. However, in the group treated with sildenafil, the increased heartbeat was slowed by 50 percent, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical stimulation. This includes nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate (Imdur, ISMO, Monoket). The results suggest that leptomeningeal fibrosis is not the only pathoanatomic basis of increased R(out) and/or B-wave activity in patients with NPH and that various degenerative changes in the parenchyma may be responsible for the altered cerebrospinal fluid dynamics characteristic of NPH. Given sildenafil peak plasma concentrations of approximately 1 μM after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes. However, I am wondering if anyone has experienced a decrease in thier sex drive becasue of it. The effects that the “average” man may experience are often mild. Sildenafil works in different ways, depending on the condition it’s being used to treat. Take care and please do keep me posted on how you are doing. However, for some men with ED, they heard only that this pill could be taken to reverse their barrier to having a great sex life. Pharmaceutical companies must pay for years of clinical trials before a drug can be deemed safe by the FDA to be on the market. Viagra (sildenafil) is an oral drug that is used for treating impotence (or erectile disfunction, ED, the inability to attain or maintain a penile erection). Postmarketing Experience The following adverse reactions have been identified during post approval use of VIAGRA. Viagra inhibits an enzyme called phosphodiesterase-5 (PDE5) which destroys the cGMP.
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