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If possible, use one pharmacy for all your prescription medications and over-the-counter products. In dose period 1, subjects were administered open-label doxazosin and a single dose of VIAGRA 50 mg simultaneously, after at least 14 consecutive days of doxazosin. Meningeal fibrosis and/or obliteration of the subarachnoid space has been suggested as the pathoanatomic basis. Examples of these drugs include: Alpha-blockers, such as terazosin, tamsulosin, doxazosin, alfuzosin, or silodosin. In addition, N-desmethyl metabolite AUC and Cmax values significantly increased by 200% and 79%, respectively in subjects with severe renal impairment compared to subjects with normal renal function. A starting dose of 25 mg should be considered in patients with severe renal impairment [see DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY]. Grapefruit and grapefruit juice may interact with sildenafil and lead to unwanted side effects. Patients should always ask their doctors for medical advice about adverse events.