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It is not recommended to mix one or more PDE5 inhibitors at the same time, as this can result in overdose. Drinking alcohol decreases the blood flow to your penis, making it harder to get and keep an erection.

There have been a few isolated reported incidents of heart problems in patients taking Viagra. Population pharmacokinetic data from patients in clinical trials also indicated a reduction in sildenafil clearance when it was co-administered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS]. These drugs are often used to treat similar conditions.

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When your doctor prescribes a new medication, be sure to discuss all your prescription medications and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as foods you eat. If possible, use one pharmacy for all your prescription medications and over-the-counter products.

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Table 1: Adverse Reactions Reported by ≥ 2% of Patients Treated with VIAGRA and More Frequent than Placebo in Fixed-Dose Phase II/III Studies When VIAGRA was taken as recommended (on an as-needed basis) in flexible-dose, placebo-controlled clinical trials of two to twenty-six weeks duration, patients took VIAGRA at least once weekly, and the following adverse reactions were reported: Table 2: Adverse Reactions Reported by ≥ 2% of Patients Treated with VIAGRA and More Frequent than Placebo in Flexible-Dose Phase II/III Studies The following events occurred in < 2% of patients in controlled clinical trials; a causal relationship to VIAGRA is uncertain. Sildenafil citrate works as a phosphodiesterase-5 inhibitor. Nitric oxide then activates the enzyme, guanylate cyclase, which causes the production of cyclic guanosine monophosphate (cGMP).

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Patients should always ask their doctors for medical advice about adverse events. The most common side effects of Viagra include headache, facial flushing, and upset stomach. Subgroup analyses of responses to a global improvement question in patients with psychogenic etiology in two fixed-dose studies (total n=179) and two titration studies (total n=149) showed 84% of VIAGRA patients reported improvement in erections compared with 26% of placebo. Montorsi F, McDermott TED, Morgan R, Olsson A, Schultz A, Kirkeby HJ, Osterloh IH "Efficacy and safety of fixed-dose oral sildenafil in the treatment of erectile dysfunction of various etiologies." Urology 53 (1999): 1011-8 19. I want to be able to move on and as of these last 4 weeks, I feel that I will never want or be able to have sex again. Cette maladie malheureusement est encore considérer aujourd'hui comme trop embarrassante pour en parler. When a single 100 mg dose of VIAGRA was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 160% increase in sildenafil Cmax and a 182% increase in sildenafil AUC. Sildenafil oral tablet is used to treat erectile dysfunction (ED). An African American woman’s breast crossed the line for some people. Gilad R, Lampl Y, Eshel Y, Sadeh M "Tonic-clonic seizures in patients taking sildenafil." BMJ 325 (2002): 869 36.