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If you are over 65 years old, you may find that the medication stays in your body for longer. Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Viagra only for the indication prescribed.Johns Hopkins Medicine Office of Corporate Communications Media contact: David March 410-955-1534; dmarch1@jhmi.edu October 24, 2005 VIAGRA BLUNTS EFFECTS OF STRESS ON THE HUMAN HEART Sildenafil citrate (Viagra), a drug used to treat erectile dysfunction (ED) in millions of men, reduces the stimulatory effects of hormonal stress on the heart by half, according to results of a new study by researchers at Johns Hopkins.  While sildenafil is more widely known for helping genital blood vessels expand to maintain an erection and, more recently, as a treatment for pulmonary hypertension, it has been thought to have little direct effect on the human heart.

While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), the researcher says.  This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart.  PDE5A is also the biological pathway blocked in the penis by sildenafil to promote the relaxation of blood vessels and maintain erections.  Funding for this study was provided by the National Institutes of Health (NIH), the Peter Belfer Laboratory Foundation and the Bernard Family Foundation.  The makers of the drug had no involvement in the design or support of the research. Prior authorization Many insurance companies require a prior authorization for this drug. For further information on the new patent as a pharmacy medicine (PMED), our section on 'Why is Viagra Connect available without a doctor's prescription?' has the answers. Always follow the instructions in the Patient Information Leaflet inside the VIAGRA connect packaging for the best results. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects.

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Sildenafil, the active ingredient in Viagra, is also marketed as Revatio, which is indicated for the treatment of pulmonary arterial hypertension to improve exercise ability and delay clinical worsening in men and women. Treatment with doxazosin continued for at least 7 days after dose period 1. Viagra was initially designed to help lower blood pressure but is now typically used to treat erectile dysfunction.

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Do you have any other physical conditions that may be causing it, such as other vascular problems, issues with nerves that send the arousal signal from the brain and spinal cord to the penis (common in diabetes), problems with the structure of the penis or the surrounding tissue, low testosterone, or use of tobacco, alcohol, or illegal drugs? Ainsi si vous souhaitez acheter sildenafil nous vous recommandons de toujours consulter toutes les informations nécessaire sur le site en question a savoir, numéro de tel, adresse e-mail.

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If VIAGRA connect is suitable for you: The pharmacist will sell you the product and advise you how to take VIAGRA connect correctly. These concerns were the main reasons why the FDA recommended against approval after the first two reviews. In volunteers with severe renal impairment (Clcr < 30 mL/min), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (~2 fold), approximately doubling of Cmax and AUC. Dilantin could increase the metabolism of sildenafil. Vobig MA "Retinal side-effects of sildenafil." Lancet 353 (1999): 1442 40. Possible side effects associated with treatment with Viagra include flushed skin, nausea or abdominal pain, congestion in the nose, diarrhea, vision clouded with a blue tint, headache and digestive problems.