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Two of the questions from the IIEF served as primary study endpoints; categorical responses were elicited to questions about (1) the ability to achieve erections sufficient for sexual intercourse and (2) the maintenance of erections after penetration. It is the cGMP that is primarily responsible for the erection by affecting the amount of blood that the blood vessels deliver and remove from the penis. The inhibition of PDE5 in some of these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of NO observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo. Given sildenafil peak plasma concentrations of approximately 1 μM after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes. Effects of VIAGRA on Sperm There was no effect on sperm motility or morphology after single 100 mg oral doses of VIAGRA in healthy volunteers.

VIAGRA was effective in a broad range of ED patients, including those with a history of coronary artery disease, hypertension, other cardiac disease, peripheral vascular disease, diabetes mellitus, depression, coronary artery bypass graft (CABG), radical prostatectomy, transurethral resection of the prostate (TURP) and spinal cord injury, and in patients taking antidepressants/antipsychotics and anti-hypertensives/diuretics. The FDA reviewed the drug three times before approving it. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.What is sildenafil, and how does it work (mechanism of action)? You may take it up to 4 hours before sexual activity. A: Viagra (sildenafil) should not be used in patients also using a nitrate drug for chest pain or heart problems.

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Viagra is currently only available in brand name version and there has not been a date set for the release of its generic. Female Viagra is a formula that is designed for women to boost their sexual life. Kimberly Hotz, PharmD Q: Is there a generic for Viagra? If these occur, you should contact your healthcare provider. Now we see Levitra and Cialis advertised just as often. Counseling Patients About Sexually Transmitted Diseases The use of VIAGRA offers no protection against sexually transmitted diseases.

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About 15 women who took the medication have not yet given birth. The usual dosage for Revatio is 20 mg administered three times daily. Michelle McDermott, RPh, PharmD Q: I take two drugs to control my seizure disorder caused by a car accident (Depakote and Dilantin).

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The FDA hasn’t approved Viagra itself for women to use. Viagra may help women who report having difficulties with lubrication because the increase in blood flow to the female genitals would subsequently increase lubrication. Michelle McDermott, PharmD Q: Where can one buy generic Viagra? More serious, but less frequent side effects include prolonged erection lasting more than four hours, vision changes, and loss of hearing. There are possible side effects with Viagra and it is not a bad idea to think twice about taking it. VIAGRA (50 mg) did not potentiate the increase in bleeding time caused by aspirin (150 mg). The patient this may indicate a completion of anterolateral laxity. This will need to be replicated in additional trials for it to be approved for postmenopausal women. Child dosage (ages 0–17 years) This drug has not been confirmed to be safe or effective in children younger than 18 years.