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This means that the clearance of sildenafil from the body would increase and blood concentrations of the medication could decrease. At doses above the recommended dose range, adverse reactions were similar to those detailed in Table 1 below but generally were reported more frequently. Viagra begins to work within about an hour and the effects can last for up to four hours. If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result [see WARNINGS AND PRECAUTIONS].

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Nitric oxide allows the smooth muscles inside the penis to relax, promoting more blood flow to the area during sexual arousal or stimulation. VIAGRA should not be used with REVATIO or with other PAH treatments containing sildenafil or any other PDE5 inhibitors (such as Adcirca [tadalafil]). Largest Healthcare retailer in New Dubai Highest number of 24X7 Pharmacies in the UAE Only Pharmacy Chain to represent over 100+ exclusive principal brands from across the globe. Therefore your overall cardiovascular status needs to be considered when you contemplate taking Viagra.

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Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and it is not eliminated in the urine. If it is not treated right away, priapism can permanently damage your penis sudden vision loss in one or both eyes. CONTRAINDICATIONS Nitrates Consistent with its known effects on the nitric oxide/cGMP pathway [see CLINICAL PHARMACOLOGY], VIAGRA was shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using nitric oxide donors such as organic nitrates or organic nitrites in any form either regularly and/or intermittently is therefore contraindicated.

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Priapism is a painful erection lasting for more than four hours which requires immediate medical attention and treatment. Outliers were defined as subjects with a standing systolic blood pressure of < 85 mmHg or a decrease from baseline in standing systolic blood pressure of > 30 mmHg at one or more timepoints. Noter qu’il est nécessaire que la femme soit au préalable excitée sexuellement. Nitrate drugs such as nitroglycerin and isosorbide dinitrate (which are commonly used to treat chest pain) do not mix well with Viagra, and the complications can be dangerous. Warnings for people with certain health conditions For people with heart problems: This drug can lower your blood pressure. Patients who experience symptoms (e.g., angina pectoris, dizziness, nausea) upon initiation of sexual activity should be advised to refrain from further activity and should discuss the episode with their physician [see WARNINGS AND PRECAUTIONS]. Again, now that the initial curiosity factor has disappeared, it is unclear how successful sexual dysfunction medication really is. For people with pulmonary veno-occlusive disease (PVOD): Taking this drug may worsen your heart function.