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Cialis differs from both Viagra and Levitra with regard to onset and duration of action. HOW SUPPLIED Dosage Forms And Strengths VIAGRA is supplied as blue, film-coated, rounded-diamond-shaped tablets containing sildenafil citrate equivalent to 25 mg, 50 mg, or 100 mg of sildenafil. Viagra is useful not just in treating impotence but in treating premature ejaculation, and it is estimated that over 40% of men worldwide could benefit from taking the drug. Pomeranz HD, Smith KH, Hart WM Jr, Egan RA "Sildenafil-associated nonarteritic anterior ischemic optic neuropathy." Ophthalmology 109 (2002): 584-7 46. Counterfeit medicines are dangerous because they are not manufactured safely or inspected by regulatory authorities.

Sildenafil and its major circulating N-desmethyl metabolite are both approximately 96% bound to plasma proteins. Don’t take this drug again if you’ve ever had an allergic reaction to it. Always speak with your doctor or pharmacist about dosages that are right for you. Nitric oxide allows the smooth muscles inside the penis to relax, promoting more blood flow to the area during sexual arousal or stimulation. What are the long-term implications for a society that has Viagra in its drug arsenal? In humans, VIAGRA has no effect on bleeding time when taken alone or with aspirin.

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Your physician is best able to determine if Viagra is appropriate for you or not. A: I do not know what strength Viagra (sildenafil) you take, but your physician may want to increase the strength you take. Sildenafil oral tablet is available as the brand-name drugs Viagra and Revatio. When vasodilators are used in combination, an additive effect on blood pressure may occur.

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Given sildenafil peak plasma concentrations of approximately 1 μM after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes. Individuals taking alpha-blockers should make sure they take Viagra at least 4 hours before or after taking alpha-blockers. Following at least 14 consecutive days of doxazosin, VIAGRA 50 mg or matching placebo was administered simultaneously with doxazosin 4 mg (17 subjects) or with doxazosin 8 mg (3 subjects). VIAGRA may affect the way other medicines work, and other medicines may affect the way VIAGRA works, causing side effects. The medication was first developed in England for used as an blood pressure reducer, but it worked better for penile dysfunction, so the makers decided to market it for that.

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You should be aware never to take more than the recommended Viagra dose without consulting a doctor, and to avoid mixing it with similar PDE5 inhibitors as this can increase the risk of unwanted Viagra side effects. If possible, use one pharmacy for all your prescription medications and over-the-counter products. A: Viagra (sildenafil) should not be used in patients also using a nitrate drug for chest pain or heart problems. Stop taking Viagra and get emergency medical help if you have: heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; vision changes or sudden vision loss; or erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis). Hepatic Impairment In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for C max and 85% for AUC). Efficacy Results from Controlled Clinical Studies The effect on one of the major end points, maintenance of erections after penetration, is shown in Figure 6, for the pooled results of 5 fixed-dose, dose-response studies of greater than one month duration, showing response according to baseline function. Levitra acts similarly to Viagra regarding possible side effects and onset and duration of pharmacologic action.