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Viagra inhibits an enzyme called phosphodiesterase-5 (PDE5) which destroys the cGMP. If you have any information on how Viagra effects the heart, can you include it in your reply. Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility Carcinogenesis Sildenafil was not carcinogenic when administered to rats for 24 months at a dose resulting in total systemic drug exposure (AUCs) for unbound sildenafil and its major metabolite of 29-and 42-times, for male and female rats, respectively, the exposures observed in human males given the Maximum Recommended Human Dose (MRHD) of 100 mg. For example, they have dosage forms in 25 mg, 50 mg, and 100 mg. Also we know that one of the main sx.of liver disease left untreated can be a devastating one all on its own.
Certain antifungals, such as ketoconazole or itraconazole. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat.
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VIAGRA improved these aspects of sexual function: frequency, firmness and maintenance of erections; frequency of orgasm; frequency and level of desire; frequency, satisfaction and enjoyment of intercourse; and overall relationship satisfaction. These doses represent, respectively, about 20 and 40 times the Maximum Recommended Human Dose (MRHD) on a mg/m² basis in a 50 kg subject. Also of note is that currently sildenafil has only two Food and Drug-labeled indications and that is for erectile dysfunction or treatment of pulmonary arterial hypertension. Many users experience little or no side effects whatsoever, and make Viagra a recurring part of their lifestyle.
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Matt Curley, PharmD Q: Is there a generic for Viagra? Both sildenafil and the metabolite have terminal half lives of about 4 hours. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Il faut noter que sildenafil viagra n'est pas un aphrodisiaque, ainsi pour donc profiter pleinement de son effet il est requit que l'homme soit sexuellement stimuler.
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Over half of all men with impotence are thought to have some physical (medical) cause. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine. Osol says that when given to pregnant rats with induced hypertension, Viagra: Helped arteries of the uterus grow as they should during pregnancy. "Hypertension decreases the growth and alters contractility of blood vessels in the uterus," Osol says, "but giving Viagra reversed these effects, resulting in improved function of the uterine circulation." Arterial diameters of Viagra-treated animals didn't quite match control (normal) values, "but were significantly larger than those with hypertension, suggesting that it may have increased blood flow to the uterus and placenta," Osol adds. Interferons have abortifacient effects in animals and should be assumed to have abortifacient potential in humans (see peginterferon alfa prescribing information). However, it can have a serious interaction with nitrates. CYP3A4 Inhibitors Consider a starting dose of 25 mg in patients treated with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, or saquinavir) or erythromycin. Medications for hypertension (high blood pressure) are usually fine to take with it, as far as drug interactions go. This page contains specific information for Viagra, not Revatio. Medical professionals recommend that you contact your doctor if you experience mild to moderate side effects. While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), the researcher says. This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart. PDE5A is also the biological pathway blocked in the penis by sildenafil to promote the relaxation of blood vessels and maintain erections. Funding for this study was provided by the National Institutes of Health (NIH), the Peter Belfer Laboratory Foundation and the Bernard Family Foundation. The makers of the drug had no involvement in the design or support of the research. Israilov S, Baniel J, Shmueli J, et al. "Treatment program for erectile dysfunction in patients with cardiovascular diseases." Am J Cardiol 93 (2004): 689-93 6. But, Viagra use in individuals without erectile dysfunction does not seem to have any effect. Call your doctor for medical advice about side effects.
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