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However, it can have a serious interaction with nitrates. In a study of healthy male volunteers, co-administration of sildenafil at steady state (80 mg t.i.d.) with endothelin receptor antagonist bosentan (a moderate inducer of CYP3A4, CYP2C9 and possibly of CYP2C19) at steady state (125 mg b.i.d.) resulted in a 63% decrease of sildenafil AUC and a 55% decrease in sildenafil Cmax .

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Across all trials, VIAGRA improved the erections of 43% of radical prostatectomy patients compared to 15% on placebo. Do not give VIAGRA to other people, even if they have the same symptoms that you have. Similar values for pharmacokinetic parameters were seen in normal volunteers and in the patient population, using a population pharmacokinetic approach.

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Clinical Studies In clinical studies, VIAGRA was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. John’s Wort, ginkgo, or resveratrol Lastly, you shouldn’t drink grapefruit juice while taking flibanserin. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.What is sildenafil, and how does it work (mechanism of action)?

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The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. Viagra side effects alcohol Memory-training techniques course of experiments with an early may, in total treatment of a viagra acute mountain sickness role in 2008 dr. A: Viagra (sildenafil) is classified as a phosphodiesterase 5 enzyme inhibitor. About 15 women who took the medication have not yet given birth. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state.