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Pharmacokinetics in Special Populations Geriatrics: Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma AUC values of sildenafil and its active N-desmethyl metabolite, respectively, compared to those seen in healthy younger volunteers (18-45 years). This allows your pharmacist to keep a complete record of all your prescription drugs and advise you about drug interactions and side effects. Efficacy Results from Controlled Clinical Studies The effect on one of the major end points, maintenance of erections after penetration, is shown in Figure 6, for the pooled results of 5 fixed-dose, dose-response studies of greater than one month duration, showing response according to baseline function. After the FDA determines that a drug is safe to be marketed, the pharmaceutical company has a patent on that drug for 10 to 13 years. 5 mg taken at the same time each day and without regard to sexual activity.

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You can also find helpful information on erectile dysfunction at //www.everydayhealth.com/erectile-dysfunction/guide/. Increased side effects can include low blood pressure or erections that last longer than normal. Lori Poulin, PharmD Q: Can stroke survivors take Viagra? William Gault, RPh Q: My husband is on blood pressure medications and tried Viagra. Should I ask him about increasing the dose to 200 mg?

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There are possible side effects with Viagra and it is not a bad idea to think twice about taking it. Patti Brown, PharmD Q: Is it safe to take Viagra? The current patent on Viagra is set to expire in 2011, so as long as they don't get any extensions on their patent, a generic version should be coming out at that time. Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. Always keep a current list of the drugs and supplements you take and review the list with your healthcare providers and your pharmacist.

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